Английская Википедия:Host cell factor C1
Шаблон:Short description Шаблон:Infobox gene Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein,[1] is a protein that in humans is encoded by the HCFC1 gene.[2][3]
Structure
HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.
Function
HCF1 is involved in control of the cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative longevity determinant.[4] Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.[3]
Mutations in this gene have been linked to disorders of the cobalamine metabolism.[5]
Interactions
Host cell factor C1 has been shown to interact with: Шаблон:Div col
- BAP1,[6]
- CREB3,[7][8]
- GABPA,[9]
- HDAC1,[10]
- HDAC2,[10]
- MLL,[11]
- OGT,[10]
- PDCD2,[12]
- POU2F1,[13][14]
- PPP1CA,[15]
- SIN3A,[10][11]
- SP1,[10][16]
- SUDS3,[10]
- WDR5,[10][11] and
- ZBTB17.[17]
References
Further reading
- Шаблон:Cite journal
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- ↑ GeneCards entry for HCFC1, http://genecards.org Шаблон:Webarchive
- ↑ Шаблон:Cite journal
- ↑ 3,0 3,1 Шаблон:Cite web
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- ↑ 10,0 10,1 10,2 10,3 10,4 10,5 10,6 Шаблон:Cite journal
- ↑ 11,0 11,1 11,2 Шаблон:Cite journal
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