Английская Википедия:15β-Hydroxycyproterone acetate

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Шаблон:Short description Шаблон:Drugbox

15β-Hydroxycyproterone acetate (15β-OH-CPA) is a steroidal antiandrogen and the major metabolite of cyproterone acetate (CPA).[1][2][3] It is formed from CPA in the liver by hydroxylation via the cytochrome P450 enzyme CYP3A4.[1][2][3] During therapy with CPA, 15β-OH-CPA circulates at concentrations that are approximately twice those of CPA.[4] 15β-OH-CPA has similar or even greater antiandrogen activity compared to CPA.[5] However, it has only about one-tenth of the activity of CPA as a progestogen.[6] 15β-OH-CPA also shows some glucocorticoid activity, similarly to CPA and unesterified cyproterone.[7][8]

See also

References

Шаблон:Reflist

Шаблон:Cyproterone acetate Шаблон:Androgen receptor modulators Шаблон:Glucocorticoid receptor modulators Шаблон:Progesterone receptor modulators

Шаблон:Steroid-stub Шаблон:Genito-urinary-drug-stub