Английская Википедия:18,19-Dehydrobuprenorphine

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Шаблон:Chembox

18,19-Dehydrobuprenorphine (HS-599) is a Шаблон:Not a typo derivative of buprenorphine. It has about twice the potency of buprenorphine. It has produced a long-lasting antinociceptive response in animal tests.[1]

18,19-Dehydrobuprenorphine never induced conditioned place-preference in test animals, unlike buprenorphine and morphine.[1]

18,19-Dehydrobuprenorphine has about three times higher affinity for the μ-opioid receptor but lower affinity for δ- and κ-opioid receptors when compared with buprenorphine.[1][2]

References

Шаблон:Reflist

Шаблон:Opioidergics


Шаблон:Analgesic-stub