Английская Википедия:2,3-Dichlorophenylpiperazine

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2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound from the phenylpiperazine family. It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine (mCPP), though it has been shown to act as a partial agonist of the dopamine D₂ and D₃ receptors.

Legality

2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples.

List of derivatives

1. Aripiprazole
2. Cariprazine
3. BAK 2-66
4. Brilaroxazine (formally RP5063)
5. FAUC-365 [474432-66-1]
6. CJB-090 2xHCl [595584-40-0]
7. NGB 2849 [189061-11-8]
8. NGB 2904 Fb: [189061-11-8] HCl: [189060-98-8]
9. PG-01037 2xHCl: [675599-62-9]
10. PG648
11. Aripiptranyl (Abilifarnate)
13. PGX-2000001 Шаблон:US patent
14. So-called R-22
15. So-called JJC 7−065
16. R-PG-648

Positional Isomer

Файл:3,4-DCPP structure.svg

3,4-DCPP, CAS# 57260-67-0

The positional isomer 3,4-dichlorophenylpiperazine (3,4-DCPP) is also known, and acts as both a serotonin releaser via the serotonin transporter, and a β₁-adrenergic receptor blocker, though with relatively low affinity at both targets.

Triple Substituted

The 3,4,5-Trichlorophenylpiperazine [67305-64-0] ("3 stripes") is also a highly regarded arrangement & has been awarded the Beecham patent of Шаблон:US patent. Such 3,4,5-Trisubstituted aromatic entities is already known from clenbuterol. Leading to CID:151687078 Шаблон:Cite patent (Ex 6 is a concrete example of this) i.e. 1-(4-Amino-3,5-dichlorophenyl)-4-(4-phthalimido-1- butyl)piperazine.

See also

• Substituted piperazine
• Phenylpiperazine

External links

• Шаблон:Commonscatinline