Английская Википедия:2-dehydropantoate 2-reductase

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Шаблон:Short description Шаблон:Infobox enzyme In enzymology, a 2-dehydropantoate 2-reductase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NADP+ <math>\rightleftharpoons</math> 2-dehydropantoate + NADPH + H+

Thus, the two substrates of this enzyme are (R)-pantoate and NADP+, whereas its 3 products are 2-dehydropantoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.

References

Шаблон:Reflist

Шаблон:Alcohol oxidoreductases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:1.1.1-enzyme-stub