Английская Википедия:25-Hydroxycholesterol

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Use dmy datesШаблон:Cs1 configШаблон:Chembox25-Hydroxycholesterol is a derivative of cholesterol, which plays a role in various biological processes in humans and other species. It is involved in cholesterol metabolism, antivirus process, inflammatory and immune response, and survival signaling pathway. 25-hydroxycholesterol is biosynthesized from cholesterol by adding a hydroxyl group at the position 25-carbon of a steroid nucleus. This reaction is catalyzed by cholesterol 25-hydroxylase, a family of enzymes that use oxygen and a di-iron cofactor to catalyze hydroxylation reaction.[1][2]

The CYP3A4 enzyme, a member of the cytochrome P450 family, can catalyze the oxidation of 25-hydroxycholesterol to 7α,25-dihydroxycholesterol, whereas 25-hydroxycholesterol can inhibit CYP4F2 mRNA expression, so that members of the cytochrome P450 family are also involved in the metabolism of 25-hydroxycholesterol besides cholesterol 25-hydroxylase.[3]

25-hydroxycholesterol has been found in various organisms such as mice, rats, rabbits, and cows. Шаблон:As of its presence in other species has not been extensively studied.[2][1]

See also

References

Шаблон:Reflist

Further reading


Шаблон:Authority control