Английская Википедия:25N-NBPh

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25N-NBPh (NBPh-2C-N) is a phenethylamine derivative from the 25-NB class, which acts as a potent agonist at the 5-HT2A receptor with weaker activity at 5-HT2B and 5-HT2C. 25N-NBPh is a biased agonist, producing robust activation of 5-HT2A coupled signalling pathways mediated by beta arrestin 2, but with only slight activation of pathways mediated via Gq. In animal studies it produces a modest head-twitch response when administered by itself, but blocks the effects of the fully active psychedelic DOI. [1][2][3]

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References

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Шаблон:Serotonin receptor modulators Шаблон:Phenethylamines

Шаблон:Hallucinogen-stub

  1. Шаблон:Cite patent
  2. Шаблон:Cite journal
  3. Wallach, J., Cao, A.B., Calkins, M.M. et al. Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential. Nat Commun 2023; 14, 8221. Шаблон:Doi