Английская Википедия:3,3'-Diindolylmethane

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Шаблон:Short description Шаблон:More medical citations needed Шаблон:Chembox

3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.[1] It and its parent compound Шаблон:Ndash indole-3-carbinol Шаблон:Ndash are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms.[1][2][3] DIM is sold as a dietary supplement.[1]

Properties

In vitro, DIM has action as a histone deacetylase inhibitor,[1] specifically against HDAC1, HDAC2, and HDAC3.[4] DIM is a metabolite of indole-3-carbinol.[1][2][3] DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2.[5][6]

Researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, have identified that 3,3′-Diindolylmethane (DIM) – a naturally occurring molecule also referred to as bisindole – can reduce biofilms responsible for plaque and cavities by a remarkable 90%. [7]

See also

References

Шаблон:Reflist

External links

Шаблон:HDAC inhibitors