Английская Википедия:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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Шаблон:Short description Шаблон:Infobox enzyme In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

ATP + 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate <math>\rightleftharpoons</math> ADP + 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate

Thus, the two substrates of this enzyme are ATP and 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME), whereas its two products are ADP and 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-MEP).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase, and IspE. This enzyme participates in the MEP pathway (non-mevalonate pathway) of isoprenoid precursor biosynthesis.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.

References

• Шаблон:Cite journal
• Шаблон:Cite journal

Шаблон:2.7-enzyme-stub