Английская Википедия:4-Dimethylamino-4-(p-tolyl)cyclohexanone

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Шаблон:Short description

Шаблон:Drugbox

4-Dimethylamino-4-(p-tolyl)cyclohexanone (sometimes known as dimetamine)[1] is a narcotic analgesic with an arylcyclohexylamine chemical structure. It was developed by Daniel Lednicer at Upjohn in the 1970s.[2] It has around the same analgesic potency as morphine, with analogues where the p-methyl group is replaced by chlorine or bromine being slightly weaker. However derivatives where the ketone group has been reacted with a Grignard reagent to add a phenethyl substitution are several hundred times stronger, and in this series it is the bromo compound BDPC that is the most potent.[3][4][5]

Legal Status

4-Dimethylamino-4-(p-tolyl)cyclohexanone is specifically listed as an illegal drug in Latvia.[6] It is also covered by drug analogue laws in various jurisdictions as a generic arylcyclohexylamine derivative.

See also

References

Шаблон:Reflist

Шаблон:Analgesics Шаблон:Opioidergics

  1. This is ambiguous, as Dimetamine is also the name of an unrelated alkaloid, as well as a trade name for propylhexedrine.
  2. Шаблон:Cite patent
  3. Шаблон:Cite journal
  4. Шаблон:Cite journal
  5. Шаблон:Cite journal
  6. Шаблон:Cite web