Английская Википедия:4-Hydroxymandelic acid

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4-Hydroxymandelic acid is a chemical compound used to synthesize atenolol.[1] The compound typically occurs as a monohydrate.

Synthesis and occurrence

It is produced from 4-hydroxypyruvic acid by the action of the enzyme (S)-p-hydroxymandelate synthase:

HOC6H4CH2C(O)CO2H + O2 → HOC6H4CH(OH)CO2H + CO2

4-Hydroxymandelic acid can be synthesized by the condensation reaction of phenol and glyoxylic acid:[1]

HOC6H5 + CHOCO2H → HOC6H4CH(OH)CO2H

See also

References

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