Английская Википедия:5-HT1B receptor
Шаблон:Infobox gene 5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.[1][2] The 5-HT1B receptor is a 5-HT receptor subtype.[3]
Tissue distribution and function
5-HT1B receptors are widely distributed throughout the central nervous system with the highest concentrations found in the frontal cortex, basal ganglia, striatum, and the hippocampus.[4] The function of the 5-HT1B receptor differs depending upon its location. In the frontal cortex, it is believed to act as a terminal receptor inhibiting the release of dopamine. In the basal ganglia and the striatum, evidence suggests 5-HT signaling acts on an autoreceptor, inhibiting the release of serotonin[5] and decreasing glutamatergic transmission by reducing miniature excitatory postsynaptic potential (mEPSP) frequency,[6] respectively. In the hippocampus, a recent study has demonstrated that activation of postsynaptic 5-HT1B heteroreceptors produces a facilitation in excitatory synaptic transmission which is altered in depression.[7] When the expression of 5-HT1B in human cortex was traced throughout life, significant changes during adolescence were observed, in a way that is strongly correlated with the expression of 5-HT1E.[8]
Outside of the CNS, the 5-HT1B receptor is also expressed on the endothelium of blood vessels, particularly in the meninges.[9] Activation of these receptors results in vasoconstriction. The high distribution of vasoconstrictive 5-HT1B and 5-HT1D receptors around the brain makes them a valuable drug target for the treatment of migraines.[9]
Blocking 5-HT1B receptor signalling also increases the number of osteoblasts, bone mass, and the bone formation rate.[10]
Knockout mice lacking the 5-HT1B gene have been reported to have a higher preference for alcohol, although later studies failed to replicate such abnormalities in alcohol consumption.[11] These mice have also been reported to have a lower measure of anxiety (such as on the elevated plus maze test) and a higher measure of aggression.[11]
Under basal conditions, knockout mice present with a "normal" phenotype and exhibit a sucrose preference (lack of sucrose preference is considered a measure of anhedonia). However, after undergoing chronic unpredictable stress treatment to induce a "depression-like" phenotype these animals do not benefit from administration of selective serotonin reuptake inhibitor (SSRIs).[7]Шаблон:Failed verification
Ligands
Agonists
- Ergotamine (vasoconstrictor in migraine)
- Oxymetazoline
- Sumatriptan (vasoconstrictor in migraine)
- Zolmitriptan
- 5-Carboxamidotryptamine
- CGS-12066A
- CP-93,129 (peripherally acting)
- CP-94,253
- CP-122,288 (mixed 5-HT1B/1D agonist)
- CP-135,807 (mixed 5-HT1B/1D agonist)
- RU-24969 (mixed 5-HT1A/1B agonist)
Partial agonists
Antagonists and inverse agonists
- Methiothepin (antipsychotic)
- Yohimbine (aphrodisiac)
- Metergoline
- Aripiprazole
- Isamoltane
- AR-A000002[12]
- SB-216,641
- SB-224,289 (inverse agonist)[13]
- SB-236,057 (inverse agonist)[14]
Undetermined Action
Genetics
In humans the protein is coded by the gene HTR1B.
A genetic variant in the promoter region, A-161T, has been examined with respect to personality traits and showed no major effect.[16]
See also
References
Further reading
- Шаблон:Cite journal
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External links
Шаблон:NLM content Шаблон:G protein-coupled receptors Шаблон:Serotonergics
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