Английская Википедия:5-MeO-DMT

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Файл:Bufo alvarius1.jpg

Colorado River toad

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado River toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. Slang terms include Five-methoxy, the power, bufo, and toad venom.

Chemistry

5-MeO-DMT was first synthesized in 1936, and in 1959 it was isolated as one of the psychoactive ingredients of Anadenanthera peregrina seeds used in preparing Yopo snuff. It was once believed to be a major component of the psychoactive effects of the snuff, although this has recently been shown to be unlikely, due to the limited or sometimes even non-existent quantity contained within the seeds, which instead achieve their psychoactivity from the O-demethylated metabolite of 5-MeO-DMT, bufotenin. It is metabolized mainly by CYP2D6.

Effects

Depending on whether smoked or insufflated, total duration of experience can last between 10 minutes for the former, or up to 2 hours for the latter. Effects vary and can range from radical perspective shifting and perception of new insights, euphoria, immersive experiences, dissociation and non-responsiveness, sensual/erotic enhancement, to dysphoria, fear, terror, panic, and ego death.Шаблон:Better source needed

Uses

It has anti-anxiety and anti-depressant effects.

Religious use

The Church of the Tree of Life, founded in California in 1971 by John Mann but now defunct, declared the use of 5-MeO-DMT to be a sacrament. From approximately 1971 to the late 1980s, 5-MeO-DMT was discreetly available to its members. Between 1970 and 1990, smoking of 5-MeO-DMT on parsley was probably one of the two most common forms of ingestion in the United States.Шаблон:Unreliable source?

Pharmacology

5-MeO-DMT is a methoxylated derivative of DMT. While most common psychedelics are believed to primarily elicit psychological effects through agonism of serotonin 5-HT_2A receptors, 5-MeO-DMT shows 1000-fold greater affinity for 5-HT_1A over 5-HT_2A; In line with its affinity for 5-HT_1A receptors, 5-MeO-DMT is extremely potent at suppressing the firing of dorsal raphe 5-HT neurons. Further, its activity in rats was attenuated with the 5-HT_1A selective antagonist WAY-100635 while 5-HT_2A selective antagonist volinanserin failed to demonstrate any change. Additional mechanisms of action such as inhibition of monoamine reuptake may be involved. A 2019 European study with 42 volunteers showed that a single inhalation produced sustained enhancement of satisfaction with life, and easing of anxiety, depression, and post-traumatic stress disorder (PTSD). A 2018 study demonstrated that a single dose of 5-MeO-DMT induced neurogenesis in mice.

Clinical development

5-MeO-DMT is being developed and evaluated for potential therapeutic effects in patients with Treatment-Resistant Depression (TRD). Biopharmaceutical company GH Research has sponsored a completed phase 1 study in healthy volunteers and phase 1/2 study in TRD patients where 87.5% of patients with TRD were brought into remission on day 7 in the phase 2 part of the study. GH Research is currently planning a phase 2b study in TRD patients and have received approval for studies in patients with bipolar II disorder and a current depressive episode and patients with postpartum depression.

Beckley Psytech in collaboration with King's College London research the safety and tolerability of intranasal 5-MeO-DMT in healthy subjects, in a phase 1 study. Beckley Psytech CEO Cosmo Feilding-Mellen sees a potential in the short-acting nature of 5-MeO-DMT compared to psilocybin: "Requiring one or two therapists to sit in a room with a single patient for the entire duration of an MDMA or psilocybin experience, which is essentially a whole working day, is probably going to be very resource-intensive and expensive. There is already a global shortage of psychotherapists, and this poses a potential bottleneck to patient access in the future."

Sources

In addition to naturally-occurring sources, 5-MeO-DMT can be produced synthetically.

Plant sources

Family	Plants
Rutaceae	Dictyoloma incanescens, Limonia acidissima, Melicope leptococca
Fabaceae	Anadenanthera peregrina, Acacia auriculiformis, Acacia victoriae, Desmodium gangeticum, Lespedeza bicolor, Mimosa pudica, Mucuna pruriens, Phyllodium pulchellum
Poaceae	Phalaris tuberosa
Malpighiaceae	Diplopterys cabrerana
Cactaceae	Echinocereus salm-dyckianus, Echinocereus triglochidiatus
Myristicaceae	Horsfieldia superba, Iryanthera macrophylla, Osteophloeum platyspermum, Virola theiodora, V. calophylla, V. multinervia, V. peruviana, V. rufula, V. venosa

Animal Sources

Family	Animals
Bufonidae	Colorado River toad (Incilius alvarius)

The Colorado River toad is a noted animal source of 5-MeO-DMT. First described in 1983 by Ken Nelson (writing under the pseudonym of Albert Most), smoking the parotoid secretions of the animal produces a powerful and short-lived psychedelic experience. The smoking of I. alvarius secretions should not be confused with the urban legend of toad licking. Since 1983, the animal has since became a popular source of 5-MeO-DMT for recreational or spiritual purposes. Unfortunately, this increased demand and use of the toads as a source of 5-MeO-DMT has put strain on their populations. Concerned with the ecological impacts of the growing use of I. alvarius secretions as a source of 5-MeO-DMT, Ken Nelson would later advocate for the use of synthetic 5-MeO-DMT and conservation of the Colorado River Toad.

Fungal Sources

Family	Fungi
Amanitaceae	Amanita citrina, Amanita porphyria

Legal status

Australia

As a structural analog of N,N-dimethyltryptamine (DMT), 5-MeO-DMT is a Schedule 9 prohibited substance under the Poisons Standard.

Canada

5-MeO-DMT is legal for personal use and possession in Canada, though sale, distribution, and other activities involving the substance are illegal under Canadian federal law.

China

As of October 2015, 5-MeO-DMT is a controlled substance in China.

Germany

As of 2001 5-MeO-DMT is listed as a controlled substance. Attachement I BtMG. BGBl. I 2001, 1180 - 1186;

Sweden

Sveriges Grodminister health ministry Statens folkhälsoinstitut classified 5-MeO-DMT, listed as 5-metoxi-N,N-dimetyltryptamin (5-MeO-DMT) in their regulation SFS 2004:696, as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) in October 2004, making it illegal to sell or possess.

Turkey

5-MeO-DMT has been controlled in Turkey since December 2013.

United States

5-MeO-DMT was made a Schedule I controlled substance in January 2011.

See also

• 4-MeO-DMT
• 5-MeO-AMT
• 5-MeO-DIPT
• 5-EtO-DMT
• 5-MeO-MET
• Dimemebfe
• EMDT
• Hamilton's Pharmacopeia
• List of entheogens
• Psychoplastogen

External links

• Erowid's 5-MeO-DMT Vault
• 5-MeO-DMT Entry in TiHKAL • info