Английская Википедия:5-Methoxytryptamine

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5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.

5-MT acts as a full agonist at the 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₆, and 5-HT₇ receptors. It has no affinity for the 5-HT₃ receptor and its affinity for the 5-HT_1E receptor is very weak in comparison to the other 5-HT₁ receptors. Its affinity for the 5-HT_5A receptor is unknown.

Файл:Indorenate structure.png

Indorenate

Measured affinity for some receptors (incomplete list):

• 5-HT_1B receptors (K_i = 35 nM)
• 5-HT_1D receptors (K_i = 7.3 nM)
• 5-HT_1E receptors (K_i = 3151 nM)
• 5-HT_1F receptors (K_i = 1166 nM)
• 5-HT_2A receptors (K_i = 295 nM)
• 5-HT_2B receptors (K_i = 16.4 nM)
• 5-HT_2C receptors (K_i = 52.48 nM)
• 5-HT₄ receptors (K_i = 501.18 nM)
• 5-HT₆ receptors (K_i = 69.18 nM)
• 5-HT₇ receptors (K_i = 5.01 nM)

See also

• 2-Methyl-5-hydroxytryptamine
• 5-Benzyloxytryptamine
• 5-Carboxamidotryptamine
• α-Methyl-5-hydroxytryptamine