Английская Википедия:AC927

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Шаблон:Short description Шаблон:More citations needed Шаблон:Drugbox

AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.[1]

AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.[1]

References

Шаблон:Reflist

Шаблон:Sigma receptor modulators