Английская Википедия:ACVR1C

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Шаблон:Short description Шаблон:Infobox gene

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.[1]

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[2]

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[1]

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Шаблон:TGF beta signaling Шаблон:Serine/threonine-specific protein kinases Шаблон:Enzymes Шаблон:TGFβ receptor superfamily modulators Шаблон:Portal bar