Английская Википедия:ADAMTS8

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Шаблон:Short description Шаблон:Infobox gene A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.[1][2]

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.[2]

Clinical significance

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.[2]

References

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Further reading

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External links

Шаблон:NLM content Шаблон:Metalloproteinases


Шаблон:Enzyme-stub