Английская Википедия:AP4E1

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Шаблон:Short description Шаблон:Infobox gene AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene.[1]

Function

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1).[1]

Clinical relevance

It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[2]

References

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External links

Further reading

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