Английская Википедия:Abafungin

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Шаблон:Short description Шаблон:Drugbox

Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

Abasol is a topical cream formulation of abafungin by York Pharma.[1]

History

Abafungin was first synthesized at Bayer AG, Leverkusen, Germany. A study of H2-antagonists related to famotidine, resulted in the discovery of its antifungal properties.[2]

Its development seems to have been discontinued in 2009.[3]

Mechanism of action

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.[2]

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.[4]

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[5]

References

Шаблон:Reflist

External links

Шаблон:Antifungals


Шаблон:Antimicrobial-stub