Шаблон:Infobox medical condition (new)Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignantexocrine tumour of the pancreas. It represents 5% of all exocrine tumours of the pancreas, making it the second most common type of pancreatic cancer.[1] It is abbreviated ACC. It typically has a guarded prognosis.
The disease is more common in men than women and the average age at diagnosis is about 60.[2]
Symptoms are often non-specific and include weight loss. A classic presentation, found in around 15% of cases includes subcutaneous nodules (due to fat necrosis) and arthralgias, caused by a release of lipase.[2]
Pathology
ACC is associated with increased serum lipase and manifests in the classic presentation known as the Schmid triad (subcutaneous fat necrosis, polyarthritis, eosinophilia).[3]
ACC are typically large, up to 10 cm, and soft compared to pancreatic adenocarcinoma, lacking its dense stroma. They can arise in any part of the pancreas.[2]
Histomorphologically, the tumour resembles the cells of the pancreatic acini and, typically, have moderate granular cytoplasm that stain with both PAS and PASD.[4]
ACC can be treated with a Whipple procedure or (depending on the location within the pancreas) with left partial resection of pancreas.Шаблон:Citation needed
↑ 2,02,12,2Von Hoff": Daniel D. Von Hoff, Douglas Brian Evans, Ralph H. Hruban, eds. Pancreatic Cancer, 2005, Jones & Bartlett Learning, Шаблон:ISBN, 9780763721787
