Английская Википедия:Akuammine

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Akuammine (vincamajoridine[1]) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida,[2] commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major.[1] Akuammine is structurally related to yohimbine, mitragynine and more distantly Voacangine, all of which are alkaloid plant products with pharmacological properties.

Pharmacology

Akuammine has antimalarial activity,[2] and may be the primary constituent of P. nitida seeds responsible for this activity.[3]

Akuammine is an opioid agonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.[4][5]

References

Шаблон:Reflist

Шаблон:Opioidergics