Английская Википедия:Albicidin

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Albicidin is an antibiotic and phytotoxic molecule produced by the bacterium Xanthomonas albilineans which infects sugarcane causing leaf scald.[1]

As a phytotoxin, it acts by inhibiting the differentiation of chloroplasts.[2] It accomplishes this by inhibiting DNA gyrase, and thereby preventing the replication of chloroplast DNA.[3] As such it plays a major role in leaf scald disease.

As a DNA gyrase inhibitor, albicindin also has potential therapeutic use as an antibiotic.[4] Its antibiotic properties were discovered in the early 1980s, when the molecule was isolated and purified from cultures of Xanthomonas albilineans.[5] However, the precise structure of the molecule was only identified in 2015.[6] A laboratory synthesis of albicidin has been developed,[1] and research is currently focused on the design and evaluation of synthetic derivatives of albicidin with improved properties.[7][8][9]

References

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