Английская Википедия:Alkanolamine
In organic chemistry, alkanolamines (amino alcohols) are organic compounds that contain both hydroxyl (Шаблон:Chem2) and amino (Шаблон:Chem2, Шаблон:Chem2, and Шаблон:Chem2) functional groups on an alkane backbone. Most alkanolamines are colorless.[1]
- Alkanolamines
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methanolamine, from the reaction of ammonia with formaldehyde
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2-amino-2-methyl-1-propanol is a precursor to oxazolines
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Sphingosine is a component of some cell membrane.
1-Aminoalcohols
1-Aminoalcohols are better known as hemiaminals. Methanolamine is the simplest member.
2-Aminoalcohols
2-Aminoalcohols are an important class of organic compounds that are often generated by the reaction of amines with epoxides:
Simple alkanolamines are used as solvents, synthetic intermediates, and high-boiling bases.[2]
Hydrogenation or hydride reduction of amino acids gives the corresponding 2-aminoalcohols. Examples include prolinol (from proline), valinol (from valine), tyrosinol (from tyrosine).
Key members: ethanolamine, dimethylethanolamine, N-methylethanolamine, Aminomethyl propanol. Two popular drugs, often called alkanolamine beta blockers, are members of this structural class: propranolol, pindolol. Isoetarine is yet another medicinally useful derivative of ethanolamine.Шаблон:Citation needed
1,3-, 1,4-, and 1,5-amino alcohols
- Heptaminol, a cardiac stimulant
- Propanolamines
Natural products
Most proteins and peptides contain both alcohols and amino groups. Two amino acids are alkanolamines, formally speaking: serine and hydroxyproline.
- Veratridine and veratrine
- Tropane alkaloids such as atropine
- hormones and neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline)
References
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