Английская Википедия:Alpha-actinin-1

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Шаблон:Short description Шаблон:Infobox gene Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.[1]

Function

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha-actinin-1 is an F-actin cross-linking protein – a bundling protein that is thought to anchor actin to a number of intracellular structures.[2] Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.[3]

Interactions

Alpha-actinin-1 has been shown to interact with:

See also

References

Шаблон:Reflist

Further reading

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External links

Шаблон:PDB Gallery Шаблон:Cytoskeletal Proteins