Английская Википедия:Alpha granule

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Шаблон:Short description Шаблон:Infobox anatomy Alpha granules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules that perform different functions, and include alpha granules, dense granules, and lysosomes.[1] Of these, alpha granules are the most common,[1] making up 50% to 80% of the secretory granules.[2] Alpha granules contain several growth factors.[3]

Contents

Contents include insulin-like growth factor 1, platelet-derived growth factors, TGF beta, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V,[4] and von Willebrand factor).[5]

The alpha granules express the adhesion molecule P-selectin[6] and CD63.[7] These are transferred to the membrane after synthesis.

The other type of granules within platelets are called dense granules.

Clinical significance

A deficiency of alpha granules is known as gray platelet syndrome.

See also

References

Шаблон:Reflist

Шаблон:Granule contents Шаблон:Authority control


Шаблон:Molecular-cell-biology-stub Шаблон:Circulatory-stub