Английская Википедия:Amino acid transporter
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An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.
Families
There are several families that function in amino acid transport, some of these include:
- TC# 2.A.3 - Amino Acid-Polyamine-Organocation (APC) Superfamily
- TC# 2.A.18 - Amino Acid/Auxin Permease (AAAP) Family
- TC# 2.A.23 - Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
- TC# 2.A.26 - Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
- TC# 2.A.42 - Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
- TC# 2.A.78 - Branched Chain Amino Acid Exporter (LIV-E) Family
- TC# 2.A.95 - 6TMS Neutral Amino Acid Transporter (NAAT) Family
- TC# 2.A.118 - Basic Amino Acid Antiporter (ArcD) Family
- TC# 2.A.120 - Putative Amino Acid Permease (PAAP) Family
Solute carrier family examples
- (1) high affinity glutamate and neutral amino acid transporter[1]
- (3) heavy subunits of heteromeric amino acid transporters[2]
- (6) Bacterial Leucine Transporter (LeuT)[3]
- (7) cationic amino acid transporter/glycoprotein-associated[4]
- (15) proton oligopeptide cotransporter[5]
- (17) vesicular glutamate transporter[6]
- (18) vesicular amine transporter[7]
- (25) some mitochondrial carriers[8]
- (26) multifunctional anion exchanger[9]
- (32) vesicular inhibitory amino acid transporter[10]
- (36) proton-coupled amino acid transporter[11]
- (38) System A & N, sodium-coupled neutral amino acid transporter[12]
VIAAT
Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]
Human proteins containing this domain
SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.
See also
- Solute carrier family
- Amino acid transport
- Amino acid transport, acidic
- Amino acid transport, basic
- Amino acid transport disorder
- Amino acid
- Transporter Classification Database
References
Шаблон:GABA metabolism and transport modulators Шаблон:Glutamate metabolism and transport modulators
- ↑ Шаблон:Cite journal
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- ↑ Шаблон:Cite journal
- ↑ [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003