Английская Википедия:Aminoaciduria

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Шаблон:Infobox medical condition (new) Aminoaciduria occurs when the urine contains abnormally high amounts of amino acids.[1] In the healthy kidney, the glomeruli filter all amino acids out of the blood, and the renal tubules then reabsorb over 95% of the filtered amino acids back into the blood.[2]

In overflow aminoaciduria, abnormally high concentrations of amino acids in the blood plasma overwhelm the resorptive capacity of the renal tubules, resulting in high concentrations of amino acids in the urine.It is estimated that about 20 to 25% of the inmates of lunatic asylums are suffering from one of the aminoacidurias[3] This may be caused by congenital disorders of amino acid metabolism,[2] for example, phenylketonuria,[4] or may be secondary to liver disease.[2]

In renal aminoaciduria, the renal tubules are unable to reabsorb the filtered amino acids back into the blood, causing high concentrations of amino acids in the urine.[4] This may be caused by a defect in the transport proteins in the renal tubule, for example, as occurs in Hartnup disease,[4] or may be due to damage to the kidney tubule, for example, as occurs in Fanconi syndrome.[3]

References

Шаблон:Reflist

External links

Шаблон:Medical resources Шаблон:Abnormal clinical and laboratory findings for urine Шаблон:Amino acid metabolic pathology


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