Английская Википедия:Androstanediol glucuronide

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Шаблон:Cs1 config Шаблон:Chembox Шаблон:Technical 3α-Androstanediol glucuronide (3α-ADG) is a metabolite formed from human androgens; compounds involved in the development and maintenance of sexual characteristics. It is formed by the glucuronidation of both dihydrotestosterone and testosterone,[1] and has been proposed as means of measuring androgenic activity.[2]

In women the adrenal steroids, dehydroepiandrosterone sulfate, androstenedione and dehydroepiandrosterone are the major precursors of plasma 3α-ADG, accounting for almost the totality of circulating 3α-ADG. Levels of 3α-ADG decrease significantly with age.[3]

3α-ADG is used as a marker of target tissue cellular action.[4] 3α-ADG correlates with level of 5α-reductase activity (testosterone and 3α-androstanediol to dihydrotestosterone) in the skin. Concentrations of 3α-ADG are associated with the level of cutaneous androgen metabolism.

See also

References

Шаблон:Reflist

Шаблон:Endogenous steroids