Английская Википедия:Annexin A6

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Шаблон:Short description Шаблон:Infobox gene Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.[1]

Function

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.[2]

Interactions

ANXA6 has been shown to interact with RAS p21 protein activator 1.[3]

References

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Further reading

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External links

Шаблон:PDB Gallery