Английская Википедия:Anti-apoptotic Ras signalling cascade

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Шаблон:Short description The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade that involves the Ras protein and inhibits apoptosis. It is the target of the cancer drug gefitinib.

It may refer to the PI3K/AKT pathway.[1][2][3]

It may refer to the MAPK/ERK pathway which involves ras and can affect apoptosis.[4][5]

The anti-apoptotic STAT pathway does not involve Ras.

See also

References

Шаблон:Reflist

External links

  • [1] Diagram of ras onwards.


Шаблон:Cell-cycle-stub

  1. Шаблон:Cite journal
  2. http://genesdev.cshlp.org/content/11/6/701.abstract "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal" 1997
  3. Шаблон:Cite journal
  4. http://cancerres.aacrjournals.org/cgi/content/abstract/67/21/10343 "Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras" 2007
  5. http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005