Английская Википедия:Arginine/lysine

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:One source

Шаблон:Use American English Шаблон:Use dmy dates Шаблон:Infobox drug

Arginine/lysine, sold under the brand name LysaKare, is a fixed-dose combination medication used to protect the kidneys from radiation damage during cancer treatment with a radioactive medicine called lutetium (177Lu) oxodotreotide.[1] It contains L-arginine hydrochloride and L-lysine hydrochloride.[1]

The most common side effects include nausea and vomiting.[1] Arginine/lysine is also associated with hyperkalaemia (high blood potassium levels), but the frequency of this side effect is not known.[1] Side effects with arginine/lysine are usually mild or moderate.[1]

Radiation from lutetium (177Lu) oxodotreotide can cause damage when the medicine passes through tubules in the kidney.[1] Arginine and lysine interfere with the passage of lutetium (177Lu) oxodotreotide through these kidney tubules.[1] As a result, the radioactive medicine leaves the body in the urine and the kidneys are exposed to less radiation.[1]

Arginine/lysine was approved for medical use in the European Union in July 2019.[1]

Medical uses

Arginine/lysine is indicated for reduction of renal radiation exposure during peptide receptor radionuclide therapy (PRRT) with lutetium (177Lu) oxodotreotide in adults.[1]

References

Шаблон:Reflist

External links

Шаблон:Portal bar


Шаблон:Pharma-stub

  1. 1,0 1,1 1,2 1,3 1,4 1,5 1,6 1,7 1,8 1,9 Шаблон:Cite web Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.