Английская Википедия:Armstrong's acid

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Armstrong's acid (naphthalene-1,5-disulfonic acid) is a fluorescent organic compound with the formula C10H6(SO3H)2. It is one of several isomers of naphthalenedisulfonic acid. It a colorless solid, typically obtained as the tetrahydrate.[1] Like other sulfonic acids, it is a strong acid. It is named for British chemist Henry Edward Armstrong.[2]

Production and use

It is prepared by disulfonation of naphthalene with oleum:

C10H8 + 2 SO3 → C10H6(SO3H)2

Further sulfonation gives The 1,3,5-trisulfonic acid derivative.[1]

Reactions and uses

Fusion of Armstrong's acid in NaOH gives the disodium salt of 1,5-dihydroxynaphthalene, which can be acidified to give the diol. The intermediate in this hydrolysis, 1-hydroxynaphthalene-5-sulfonic acid, is also useful. Nitration gives nitrodisulfonic acids, which are precursors to amino derivatives.

The disodium salt is sometimes used as a divalent counterion for forming salts of basic drug compounds, as an alternative to the related mesylate or tosylate salts. When used in this way such a salt is called a naphthalenedisulfonate salt, as seen with the most common salt form of the stimulant drug CFT. The disodium salt is also used as an electrolyte in certain kinds of chromatography.[3]

References

Шаблон:Reflist

  1. 1,0 1,1 Gerald Booth "Naphthalene Derivatives" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, Wiley-VCH, Weinheim. Шаблон:Doi.
  2. Шаблон:Cite book
  3. Shigeru Terabe "Electrokinetic chromatography: An interface between electrophoresis and chromatography" TrAC Trends in Analytical Chemistry 1989, Volume 8, pp. 129–134. Шаблон:Doi