Английская Википедия:Arylsulfatase A

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Шаблон:Short description Шаблон:Infobox gene Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.[1][2]

Clinical significance

A deficiency in Arylsulfatase A is associated with metachromatic leukodystrophy, an autosomal recessive disease.[3] Multiple sulfatase deficiency (MSD) is also associated with the ARSA gene.[4]

Biochemistry

Enzyme regulation

Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine.[5]

References

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Further reading

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External links

Шаблон:PDB Gallery Шаблон:Esterases Шаблон:Sphingolipid metabolism enzymes


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