Английская Википедия:Aspergillus fumigatus non-coding RNAs

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Шаблон:Italic title Aspergillus fumigatus is a pathogenic filamentous fungus and is responsible for more infections worldwide than any other mould. Studies of the small non-coding RNA transcriptome of this fungus under a variety of different conditions and the subsequent generation of cDNA libraries from size selected small RNA species, identified several non-coding RNAs (ncRNA) within the fungal genome.[1] The ncRNAs identified were further classified as small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs) or novel ncRNAs. The expression of these ncRNAs was also shown to be influenced by developmental stages of the fungus and environmental conditions. Comparative genomics showed that the snoRNAs present within A. fumigatus are conserved across other strains of fungus. This study also identified several partial tRNA sequences within the cDNA libraries which corresponded to either the 5’ or 3’ halves of tRNA molecules. These partial tRNAs are thought to have been created by enonuclolytic cleavage within the anti-codon loop. It has been suggested that these partial tRNA stall protein synthesis however, further studies are required to determine their exact function. The table below summarised the type, genome location and corresponding target sites of the ncRNAs identified in A. fumigatus.

Non-Coding RNAs present in A. fumigatus

Name Size Genome Location Target Type Accession number
U1-1 132 Intergenic; Afu1g06980/Afu1g07000 snRNA AM921915
U1-2 132 Intergenic; Afu4g12490/Afu4g12500 snRNA AM921916
U5 99 Intergenic; Afu6g12670/Afu6g12680 snRNA AM921917
U6 50 Intergenic; Afu4g12500/Afu4g12520 Intergenic; Afu2g10150/Afu2g10160 snRNA AM921918
Afu-191 92 Intergenic; Afu1g10270/Afu1g10280 Gm75 in 5.8S and Am32 in U2 C/D box snoRNA AM921920
Afu-190 107 Intergenic; Afu4g11320/Afu4g11330 Gm557 in 18S C/D box snoRNA AM921921
Afu-198 130 Intergenic; Afu1g02700/Afu1g02680 Cm2856 and Um 2859 in 26S C/D box snoRNA AM921922
Afu-294 85 Intergenic; Afu1g09750/Afu1g09760 Cm1851 in 26S; Am43 in 5.8S C/D box snoRNA AM921923
Afu-264 103 Intergenic; Afu7g05290/Afu7g05300 Gm2770 and Gm2773 in 26S; C/D box snoRNA AM921924
Afu-277 100 Intergenic; Afu1g09740/Afu1g09760 Um2706 in 26S; Am97 in 18S; Cm47 in 5.8S C/D box snoRNA AM921925
Afu-188 84 Intergenic; Afu4g11310/Afu4g11320 Am25 and Um26 in 18S C/D box snoRNA AM921927
Afu-304 106 Intron 2 (sense); Afu1g09800 Cm2925 in 26S C/D box snoRNA AM921929
Afu-380 87 Intergenic; Afu4g06780/Afu4g06770 Um2701 in 26S C/D box snoRNA AM921930
Afu-513 129 Intergenic; Afu4g11310/Afu4g11320 Gm1338 and Gm3719 in 26S C/D box snoRNA AM921931
Afu-328 75 Intron 2 (sense); Afu6g04570 Gm2792 in 26S C/D box snoRNA AM921932
Afu-335 97 Intron 2 (sense); Afu1g04840 Cm2316 in 26S C/D box snoRNA AM921933
Afu-438 83 Intergenic; Afu2g15980/Afu2g15970 Am2877 in 26S C/D box snoRNA AM921934
Afu-455 92 Intergenic; Afu1g09760/Afu1g09740 Gm1122 in 18S C/D box snoRNA AM921935
Afu-40 90 Intergenic; Afu4g11310/Afu4g11320 C/D box snoRNA AM921936
Afu-514 105 Intergenic; Afu6g03830/Afu6g03840 C/D box snoRNA AM921937
Afu-515 89 Intergenic; Afu4g11310/Afu4g11320 C/D box snoRNA AM921938
Afu-199 79 Intron 1 (sense); Afu7g02320 C/D box snoRNA AM921939
Afu-298 93 Intergenic; Afu1g05080/Afu1g05100 C/D box snoRNA AM921940
Afu-300 88 Intergenic; Afu4g11310/Afu4g11320 C/D box snoRNA AM921941
Afu-215 24 Intergenic; Afu5g12870/Afu5g12880 C/D box snoRNA AM921942
Afu-511 164 Intergenic; Afu1g03400/Afu1g03410 C/D box snoRNA AM921943
Afu-210 24 Intron 2 (sense); Afu2g03610 C/D box snoRNA AM921944
Afu-265 23 Intergenic; Afu3g02340/Afu3g02370 C/D box snoRNA AM921945
Afu-182 219 Intergenic; Afu4g07680/Afu4g07690 novel AM921946
Afu-202 266 Intergenic; Afu1g10420/Afu1g10430 SRP RNA AM921947
Afu-254 163 Intergenic; Afu7g04110/Afu7g04120 novel AM921949
Afu-203 111 Intron 1 (sense); Afu3g14240 novel AM921950
Afu-309 318 Intergenic; Afu4g10430/Afu4g10420 novel AM921953

References

Шаблон:Reflist