Английская Википедия:BU72

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BU72 is an extremely potent opioid, with one of the highest known affinities for the μ-opioid receptor. In animal studies, it was found to be a potent analgesic, with a slow onset and long duration of action, but was not considered suitable to develop for medical use.[1] It was used to produce the first crystal structure of the active μ-opioid receptor,[2] and is now widely used to model the activation process.[3][4][5] The stereochemistry has recently been revised, with the phenyl group in the (R) configuration,[6] which has been accepted by the authors of the crystal structure.[7]

Файл:BU72 structure.png
BU72 original proposed structure ((S)-phenyl epimer)

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See also

References

Шаблон:Reflist


Шаблон:Pharm-stub