Английская Википедия:Basopenia

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Шаблон:Infobox medical condition (new) Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.[1] It has been proposed as an indicator of ovulation.[2] It is difficult to detect without flow cytometry, because normal levels are so low.[3] It can be defined as less than 0.01 x 109 / L.[4] Basopenia has been observed in a number of conditions, including after the administration of corticosteroids and in disease states such as chronic urticaria and lupus.[5]

Mechanism

Шаблон:Main Basophils, which account for a small proportion of the total leukocyte count, are phagocytic. Heparin, histamine, and serotonin are found in the basophilic granules. Mast cells are tissue basophils that are similar to blood basophils. Mast cells are normally not found in peripheral blood and are only rarely found in healthy bone marrow. Chronic inflammation is assessed using basophil counts. Although there is a positive correlation between higher basophil counts and high blood histamine concentrations, this correlation is not indicative of cause and effect.[6]

Associated conditions

References

Шаблон:Reflist

External links

Шаблон:Medical resources Шаблон:Monocyte and granulocyte disease