Английская Википедия:Bcl-2-associated death promoter

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Шаблон:Cs1 config Шаблон:Infobox gene Шаблон:Infobox protein family The BCL2 associated agonist of cell death[1] (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. BAD is a member of the BH3-only family,[2] a subfamily of the Bcl-2 family. It does not contain a C-terminal transmembrane domain for outer mitochondrial membrane and nuclear envelope targeting, unlike most other members of the Bcl-2 family.[3] After activation, it is able to form a heterodimer with anti-apoptotic proteins and prevent them from stopping apoptosis.

Mechanism of action

Bax/Bak are believed to initiate apoptosis by forming a pore in the mitochondrial outer membrane that allows cytochrome c to escape into the cytoplasm and activate the pro-apoptotic caspase cascade. The anti-apoptotic Bcl-2 and Bcl-xL proteins inhibit cytochrome c release through the mitochondrial pore and also inhibit activation of the cytoplasmic caspase cascade by cytochrome c.[4]

Dephosphorylated BAD forms a heterodimer with Bcl-2 and Bcl-xL, inactivating them and thus allowing Bax/Bak-triggered apoptosis. When BAD is phosphorylated by Akt/protein kinase B (triggered by PIP3), it forms the BAD-(14-3-3) protein heterodimer. This leaves Bcl-2 free to inhibit Bax-triggered apoptosis.[5] BAD phosphorylation is thus anti-apoptotic, and BAD dephosphorylation (e.g., by Ca2+-stimulated Calcineurin) is pro-apoptotic. The latter may be involved in neural diseases such as schizophrenia.[6]

Interactions

Файл:Signal transduction pathways.svg
Overview of signal transduction pathways involved with apoptosis.

Bcl-2-associated death promoter has been shown to interact with: Шаблон:Div col

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See also

References

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Further reading

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External links

Шаблон:Fas apoptosis signaling pathway

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  1. ↑ Шаблон:Cite web
  2. ↑ Шаблон:Cite journal
  3. ↑ Шаблон:Cite journal
  4. ↑ Helmreich, E.J.M. (2001) The Biochemistry of Cell Signalling, pp. 238-43
  5. ↑ E.J.M. (2001) The Biochemistry of Cell Signalling, pp. 242
  6. ↑ Foster, T.C. et al. (2001) J. Neurosci. 21, 4066-4073, "Calcineurin Links Ca++ Dysregulation with Brain Aging"(
  7. ↑ 7,0 7,1 7,2 7,3 7,4 7,5 Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
  10. ↑ Шаблон:Cite journal
  11. ↑ 11,0 11,1 Шаблон:Cite journal
  12. ↑ Шаблон:Cite journal
  13. ↑ 13,0 13,1 Шаблон:Cite journal
  14. ↑ Шаблон:Cite journal
  15. ↑ Шаблон:Cite journal
  16. ↑ Шаблон:Cite journal
  17. ↑ Шаблон:Cite journal
  18. ↑ 18,0 18,1 18,2 Шаблон:Cite journal
  19. ↑ Шаблон:Cite journal
  20. ↑ 20,0 20,1 Шаблон:Cite journal
  21. ↑ Шаблон:Cite journal
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