Английская Википедия:Benproperine

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Шаблон:Short description Шаблон:Drugbox Benproperine (INN) is a cough suppressant.[1] It has been marketed in multiple countries in Central America and Europe, as the phosphate or pamoate salts in either tablet, dragée, or syrup form. Trade names include Blascorid in Italy and Sweden, Pectipront and Tussafug in Germany, and Pirexyl in Scandinavia. The recommended dosage for adults is 25 to 50 mg two to four times daily, and for children 25 mg once or twice daily. Adverse effects include dry mouth, dizziness, fatigue, and heartburn.[2]

Synthesis

Файл:Benproperine synthesis.svg
Thieme Patents:[3][4] Revised:[5] China:[6]

The base catalyzed ether formation between 2-Benzylphenol [28994-41-4] (1) and 1,2-dichloropropane (2) gives 1-benzyl-2-(2-chloropropoxy)benzene [85909-36-0] (3). Displacement of the remaining halogen with piperidine completes the synthesis of benproperine (4).

References

Шаблон:Reflist

Шаблон:Cough and cold preparations


Шаблон:Respiratory-system-drug-stub

  1. Шаблон:Cite journal
  2. Шаблон:Cite book
  3. DK96113 idem Rubenstein K, Шаблон:Cite patent (1962 to Pharmacia AS).
  4. Kurt Rubinstein, Шаблон:US patent (1964 to Aktieselskabet Pharmacia).
  5. Byoung Mog Kwon, et al. Шаблон:Cite patent (to Korea Research Institute of Bioscience and Biotechnology KRIBB).
  6. Chin. J. Org. Chem. 2011, Vol. 31, Issue (02): 212-215.