Английская Википедия:Bentley compounds

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Шаблон:Short description

Файл:Bentley compounds single bond.svg
General structure of a Bentley compound with an ethano-bridge (single bond)
Файл:Bentley compounds double bond.svg
General structure of a Bentley compound with an etheno-bridge (double bond)

The Bentley compounds are a class of semi-synthetic opioids that were first synthesized by K. W. Bentley by Diels-Alder reaction of thebaine with various dienophiles. The compounds are also known as thevinols, orvinols, or bridged oripavine derivatives, due to the characteristic 6,14-endo-ethano- or etheno-bridge and substitution at the 7α position. Buprenorphine and etorphine are perhaps the best known of the family, which was the first series of extremely potent μ-opioid agonists, with some compounds in the series having over many thousands of times the analgesic potency of morphine.[1][2][3][4][5]

See also

References

Шаблон:Reflist

Шаблон:Opioidergics


Шаблон:Analgesic-stub