Английская Википедия:BerEp4

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Файл:BCC with squamous cell metaplasia with HE and BerEP4 staining.jpg
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4.[1]
Файл:Superficial BCC with HE and BerEP4.jpg
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease.[1] At bottom, columnar epithelium in normal sweat glands stain positive too.

BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC).[2] It is an antibody to EpCAM (epithelial cell adhesion molecule).[1]

Clinical use

BerEp4 has a high sensitivity and specificity in being positive only in BCC cells.[1] BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body.[3] It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4).[3][4]

See also

References