Английская Википедия:Bilirubin oxidase

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Шаблон:Infobox enzyme In enzymology, a bilirubin oxidase, BOD or BOx, (Шаблон:EC number) is an enzyme encoded by a gene in various organisms that catalyzes the chemical reaction

2 bilirubin + O2 <math>\rightleftharpoons</math> 2 biliverdin + 2 H2O

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is bilirubin:oxygen oxidoreductase. This enzyme is also called bilirubin oxidase M-1. This enzyme participates in porphyrin and chlorophyll metabolism. It is widely studied as a catalyst for oxygen reduction.[1]

Two structures of bilirubin oxidase from the ascomycete Myrothecium verrucaria have been deposited in the Protein Data Bank (accession codes Шаблон:PDB link and Шаблон:PDB link).[2][3]

The active site consists of four copper centers, reminiscent of laccase. These centers are classified as type I (cys, met, his, his), type II (3his), and two type III (2his).

Further reading

References

Шаблон:Reflist

Шаблон:CH-CH oxidoreductases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:1.3-enzyme-stub