Английская Википедия:Bisoctrizole
Шаблон:Multiple issues Шаблон:Chembox
Bisoctrizole (INN[1]/USAN,[2] marketed by BASF as Tinosorb M, by DSM Nutritional Products as Parsol Max , by Everlight Chemical as Eversorb M, and by MPI as Milestab 360, INCI methylene bis-benzotriazolyl tetramethylbutylphenol) is a phenolic benzotriazole that is added to sunscreens to absorb UV rays.[3] It is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays.[3] It also reflects and scatters UV.Шаблон:Fact
Bisoctrizole is what is termed is a hybrid UV absorber, which has been described as an organic UV filter produced in microfine organic particles (< 200 nm),Шаблон:Verification needed[4]Шаблон:Better source[5]Шаблон:Primary source inline like microfine zinc oxide and titanium dioxide.Шаблон:DubiousШаблон:Fact Where other organic UV absorbers dissolved in either the oily or aqueous phases, bisoctrizole dissolves poorly in both.Шаблон:Fact
Hence, bisoctrizole is formulated in sunscreen preparations as a 50% suspension, the absorber added to the water phase,Шаблон:Contradict-inline and mineral micropigments usually added to the oil phase.Шаблон:Fact The bisoctrizole particles are stabilized by the surfactant decyl glucoside.Шаблон:Fact The compound shows very little photodegradation, and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.Шаблон:Fact
In primary research reports, bisoctrizole has been reported to minimally penetrate skin,[6]Шаблон:Primary source inline and has been described as lacking estrogenic effects in vitro.[7]Шаблон:Primary source inline
As of this date,Шаблон:When bisoctrizole had not been approved by the U.S. Food and Drug Administration (FDA),Шаблон:Fact but is approved in the EU and other parts of the world.[8]Шаблон:Better source[9][10]Шаблон:Full
References
External links
- Ciba® TINOSORB® M – Microfine UV absorber with Triple Action
- http://www.dermatologytimes.com/dermatologytimes/article/articleDetail.jsp?id=159652
- NEW-WAVE SUNSCREENS – Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, C&EN Cover Story
- https://www.fda.gov/ohrms/dockets/dockets/05n0446/05n-0446-bkg0001-03-Tab-01-vol2.pdf
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ 3,0 3,1 Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journalШаблон:Primary source inline
- ↑ Шаблон:Cite journalШаблон:Primary source inline
- ↑ Шаблон:Cite journalШаблон:Primary source inline
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Australian Regulatory Guidelines for OTC Medicines, Chapter 10.Шаблон:Full
