The reaction was claimed to bring excellent yields by Blaise, however, investigators failed to obtain better than moderate yields (50%).Шаблон:RefШаблон:Ref Thus, the reaction is particularly ineffective in forming ketones from acyl chlorides. The reaction also works with organocuprates.Шаблон:RefШаблон:Ref Reviews have been written.Шаблон:RefШаблон:Ref
The mechanism is sampled from the proposed mechanism for organocadmium compounds, given that the mechanisms are identical to one another the proposed mechanism for the reaction is the same as the one for organocadmium compoundsШаблон:RefШаблон:Ref.
After the oxygen forms a bond with the organozinc compound, R’ shifts to the carbonyl carbon, having chlorine act as a leaving group and removing the negative charge from zinc. The chlorine that left returns to form a bond with zinc, pushing the electrons back on to oxygen and thus forming the ketone.Шаблон:Ref
Variations
Blaise-Maire reaction
The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.Шаблон:Ref
Ketone formation from organocadmium compounds
This ketone formation is an identical reaction to the Blaise ketone synthesis. Only instead of organozinc compounds, organocadmium compounds are used and produce higher yields.
