Английская Википедия:Brazilian hemorrhagic fever
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Brazilian hemorrhagic fever (BzHF) is an infectious disease caused by Brazilian mammarenavirus, an arenavirus.[1] Brazilian mammarenavirus is one of the arenaviruses from South America to cause hemorrhagic fever.[2] It shares a common progenitor with Argentinian mammarenavirus, Machupo mammarenavirus, Tacaribe mammarenavirus, and Guanarito mammarenavirus.[2] It is an enveloped RNA virus and is highly infectious and lethal.[3] Very little is known about this disease, but it is thought to be transmitted by the excreta of rodents.[1][3] This virus has also been implicated as a means for bioterrorism, as it can be spread through aerosols.[4]
As of 2019, there had only been four documented infections of Brazilian mammarenavirus: two occurred naturally, and the other two cases occurred in the clinical setting.[5] The first naturally occurring case was in 1990, when a female agricultural engineer who was staying in the neighborhood of Jardim Sabiá in the municipality of Cotia, a suburb of São Paulo, Brazil contracted the disease (The virus is also known as "Sabiá Virus").[6] She presented with hemorrhagic fever and died.[1] Her autopsy showed liver necrosis.[1] A virologist who was studying the woman's disease contracted the virus but survived.[1] Ribavirin was not given in these first two cases.[1] Four years later, in 1994, a researcher was exposed to the virus in a level 3 biohazard facility at Yale University when a centrifuge bottle cracked, leaked, and released aerosolized virus particles.[1][7] He was successfully treated with ribavirin.[1][8]
A fifth case, also naturally acquired in upstate São Paulo, was reported in January 2020.[9] The patient died 12 days after the onset of symptoms.[10]
Treatment
Ribavirin is thought to be effective in treating the illness, similar to other arenaviruses.[1][8] Compared to the patients who did not receive ribavirin, the patient who was treated with it had a shorter and less severe clinical course.[1] Symptomatic control such as fluids to address dehydration and bleeding may also be required.[8]
Brazilian mammarenavirus is a biosafety Level 4 pathogen.[3]
References
External links
Шаблон:Medical resources Шаблон:Zoonotic viral diseases Шаблон:Taxonbar
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- ↑ Перейти обратно: 1,0 1,1 1,2 1,3 1,4 1,5 1,6 1,7 1,8 1,9 Шаблон:Cite journal
- ↑ Перейти обратно: 2,0 2,1 Шаблон:Cite journal
- ↑ Перейти обратно: 3,0 3,1 3,2 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
- ↑ Перейти обратно: 8,0 8,1 8,2 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
