Английская Википедия:Bufadienolide

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Шаблон:Chembox Bufadienolide is a chemical compound with steroid structure. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an atrioventricular block, bradycardia (slow heartbeat), ventricular tachycardia (a type of rapid heartbeat), and possibly lethal cardiac arrest.[1]

Etymology

The term derives from the toad genus Bufo that contains bufadienolide glycosides, the suffix -adien- that refers to the two double bonds in the lactone ring, and the ending -olide that denotes the lactone structure. Consequently, related structures with only one double bond are called bufenolides,[2] and the saturated equivalent is bufanolide.[3]

Файл:Bufanolide structure.png
Bufanolide

Шаблон:Clear-left

Classification

According to MeSH, bufadienolides and bufanolides are classified as follows:[4][5]

References

Шаблон:Reflist

Further reading

Шаблон:Cardiac glycosides


Шаблон:Cardiovascular-drug-stub