Английская Википедия:Buschke–Ollendorff syndrome
Шаблон:Infobox medical condition (new) Buschke–Ollendorff syndrome (BOS) is a rare genetic skin disorder associated with LEMD3, that typically presents with widespread painless papules.[1][2]
It is inherited in an autosomal dominant manner.[3][4] Conditions that may appear similar include tuberous sclerosis, pseudoxanthoma elasticum, neurofibroma, and lipoma, among others.[1]
Its frequency is almost 1 case per every 20,000 people, and it is equally found in both males and females.[5] It is named for Abraham Buschke and Helene Ollendorff Curth, who described the condition in one female in 1928.[1][6]
Signs and symptoms
The signs and symptoms of this condition are consistent with the following (possible complications include aortic stenosis and hearing loss[7][5]):
- Osteopoikilosis
- Bone pain
- Connective tissue nevi
- Metaphysis abnormality
Pathogenesis
Buschke–Ollendorff syndrome is caused by one important factor: mutations in the LEMD3 gene (12q14), located on chromosome 12.Шаблон:Citation needed
Among the important aspects of Buschke–Ollendorff syndrome condition, genetically speaking are:[8][9][10]
- LEMD3 (protein) referred also as MAN1, is an important protein in inner nuclear membrane.
- LEMD3 gene gives instructions for producing protein that controls signaling for transforming growth factor-beta.
- LEMD3 gene helps in the bone morphogenic protein pathway
- Both of the above pathways help grow new bone cells
- BMP and TGF-β pathways controls SMADs proteins, which then bind to DNA
- LEMD3 once mutated, causes a reduction of the protein, which in turn causes excess of the above two pathways.
Diagnosis
The diagnosis of this condition can be ascertained via several techniques one such method is genetic testing, as well as:[7][12]
- X-ray
- Ultrasound
- Histological test
Differential diagnosis
The differential diagnosis for an individual believed to have Buschke–Ollendorff syndrome is the following:[12]
Treatment
In terms of the treatment of Buschke–Ollendorff syndrome, should the complication of aortic stenosis occur then surgery may be required.[5]
Treatment for hearing loss may also require surgical intervention.[5]
See also
References
Further reading
External links
Шаблон:Medical resources Шаблон:Scholia Шаблон:Cytoskeletal defects Шаблон:Medicine
- ↑ 1,0 1,1 1,2 Шаблон:Cite book
- ↑ Шаблон:OMIM
- ↑ Шаблон:Cite book
- ↑ Шаблон:Cite journal
- ↑ 5,0 5,1 5,2 5,3 Шаблон:Citation
- ↑ A. Buschke, H. Ollendorff-Curth. Ein Fall von Dermatofibrosis lenticularis disseminata und Osteopathia condensans disseminata. Dermatologische Wochenschrift, Hamburg, 1928, 86: 257–262.
- ↑ 7,0 7,1 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
-Creative Commons Attribution 3.0 Unported license - ↑ 12,0 12,1 Шаблон:Cite web
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