Английская Википедия:Butaperazine

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Шаблон:Short description Шаблон:Drugbox

Butaperazine (Repoise, Tyrylen) is a typical antipsychotic of the phenothiazine class.[1] It was approved in 1967, and possibly discontinued in the 1980s.

Synthesis

Файл:Butaperazine synthesis.svg
Patent:[2]

2-Butyrylphenothiazine [25244-91-1] (1) is the requisite starting material for carrying out the procedure. It is prepared in a manner that is synonymous with the method used in the propiomazine and propiopromazine already discussed. The 1-(γ-chloropropyl)-4-methylpiperazine [104-16-5] (2) is prepared in the conventional way from alkylating 1-methylpiperazine and 1-Bromo-3-chloropropane. Sodamide is used to extract the 10-H thereby facilitating the nucleophilic substitution reaction. And completing the instalment of the sidechain.

See also

References

Шаблон:Reflist

Шаблон:Antipsychotics Шаблон:Adrenergics Шаблон:Cholinergics Шаблон:Dopaminergics Шаблон:Histaminergics Шаблон:Tricyclics

Шаблон:Nervous-system-drug-stub

  1. Шаблон:Cite journal
  2. Dr Ulrich Hoerlein, Dr Klaus-Heinz Risse, Dr Wolfgang Wirth, Шаблон:Cite patent (1961 to Bayer Ag).