Английская Википедия:Butyrate—CoA ligase

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Шаблон:Infobox enzyme Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase (XM-ligase), is an enzyme (Шаблон:EnzExplorer) that catalyzes the chemical reaction:

ATP + a carboxylic acid + CoA <math>\rightleftharpoons</math> AMP + diphosphate + an acyl-CoA

The 3 substrates of this enzyme are ATP, carboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in the glycine conjugation of xenobiotics[1] and butanoate metabolism.

Nomenclature

The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include:

  • butyryl-CoA synthetase, fatty acid thiokinase (medium chain),
  • acyl-activating enzyme, fatty acid elongate,
  • fatty acid activating enzyme,
  • fatty acyl coenzyme A synthetase,
  • medium chain acyl-CoA synthetase,
  • butyryl-coenzyme A synthetase,
  • L-(+)-3-hydroxybutyryl CoA ligase,
  • xenobiotic/medium-chain fatty acid ligase, and
  • short-chain acyl-CoA synthetase.

Human proteins containing this domain

References

Шаблон:Reflist

Шаблон:Ligases CO CS and CN Шаблон:Enzymes Шаблон:Portal bar


Шаблон:Ligase-stub