Английская Википедия:Calcitonin receptor

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Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox gene

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,[1] particularly with respect to bone formation and metabolism.[2][3][4]

CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.[5] It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).[6]

Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.[7]

Interactions

Файл:Human calcitonin recptor-Gs complex PDB 7TYO.png
Structure of human calcitonin recptor-Gs complex. The transmembrane calcitonin receptor (blue) is bound to human calcitonin (red) and the Gs complex (yellow). Шаблон:PDB

Calcitonin receptor has been shown to interact with Apolipoprotein B[8][9] and LRP1.[10]

References

Further reading

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External links

Шаблон:G protein-coupled receptors Шаблон:Neuropeptide receptors