Английская Википедия:Calsenilin

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Шаблон:Short description Шаблон:Infobox gene Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[1][2][3]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[4][5] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.[6] Alternatively spliced transcript variants encoding different isoforms have been described.[3]

Interactions

Calsenilin has been shown to interact with PSEN1[1][7] and PSEN2.[1][8]

See also

References

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Further reading

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External links

Шаблон:NLM content Шаблон:Ion channels


Шаблон:Membrane-protein-stub